Опубликовано: 28 июня 2019
Обновлено: 17 октября 2021

HBV vaccine

HBV vaccine is a hepatitis B vaccine, which is a highly purified non-infectious surface protein (HBsAg) polypeptide of the hepatitis B virus adsorbed on aluminum hydroxide. The drug is a genetically engineered vaccine, where the production of HBsAg occurs in yeast cells.

This one of the first vaccines that a newborn child receives within 24 hours after birth.

Why vaccination is carried out : active immunization against viral hepatitis B.

Method of administration and dosage : The vaccine is injected intramuscularly into the anterolateral thigh area of ​​newborns and children under 1 year old at a dose of 0.5 ml. < / p>

Contraindications: yeast allergy

Reaction to the vaccine : Local reactions are usually noted: redness, soreness, swelling, induration, self-limiting within two days after vaccination .

General reactions: malaise, fatigue, headache, nausea, vomiting, dizziness, myalgia, arthritis.

Rare reactions: increased body temperature (higher 38.8 ° C).

Composition : 0.5ml of vaccine contains
Active ingredient: purified HBsAg -10mcg
Adjuvant : aluminum hydroxide gel -0.25 mg
Preservative: thiomersal — 0.005 mg

Excipients: monobasic potassium phosphate, sodium phosphate dibasic, sodium chloride.

Form of issue : & nbsp; 1 dose vial

BCG vaccine

BCG (Bacillus Kelmett-Guerin) — live attenuated bacterial vaccine, freeze-dried (dried) complete with solvent.

Why is it carried out vaccination : prevention of tuberculosis

Method of application and dosage : vaccination dose for newborns — 0.05 ml, injected strictly inside skin in the left shoulder.

Contraindications:

• The weight of the newborn is less than 1500 grams (vaccination is carried out when the weight reaches 2000 grams).
• Acute pathology or exacerbation of chronic diseases (for example, in the presence of intrauterine infection, hemolytic disease of newborns, neurological disorders, systemic pathologies of the skin). In the presence of these conditions, BCG vaccination is postponed until the child’s condition returns to normal.

Reaction to introduction vaccines : BCG has a specific local reaction. Together the introduction of the vaccine, an abscess develops, which is covered with a crust and heals. After healing and falling off of the crust, a scar remains in size 3-10 mm, indicating the setting of this vaccination.

Rare collateral reactions :

• superficial ulcer
• subcutaneous abscesses
• regional lymphadenitis
• keloid scar

The reaction to the vaccine is delayed, since forms 4-6 weeks after injection.

Composition :
Main component: 70% live weakened microbes — 0.5 mg
Excipient: sodium glutamate
Solvent: isotonic sodium solution

Release form : & nbsp; 20-dose vial & nbsp;

DTP-HBV-CIB (liquid combination pentavaccine)

Pentavaccine — & nbsp; This is a combination multi-component vaccine consisting of 5 antigens. The active part of the vaccine includes purified diphtheria and tetanus toxins, inactivated particles of pertussis, highly purified non-infectious HBsAg particles, components of Haemophilus influenzae type b.

Why is it carried out vaccination: active immunization against diphtheria, pertussis, tetanus, viral hepatitis B and hemophilus influenza type «b».

Method of application and dosage : the vaccine is intended only for intramuscular administration in anterolateral thigh at a dose of 0.5 ml.

Contraindications: increased sensitivity to any of the components of the vaccine or a serious reaction to the previous dose of the combination vaccine or any of its components.

Reaction to vaccine administration: local reactions: redness, induration, soreness.

General reactions: irritability, tearfulness, slight fever usually occurs within 48 hours after vaccination and in in most cases, they pass within two to three days on their own without medical care.

All local and general reactions disappear without consequences.

Rare collateral reactions :

• Increase in body temperature above 39.5 ° С (1 case per 15 & nbsp; 000 doses administered)
• Febrile convulsions (1 case per 12 & nbsp; 500 doses administered)
• Constant crying for more than 3 hours within 48 hours after vaccine administration (1 case per 3000 doses administered)
• Allergic reactions (urticaria, Quincke’s edema, anaphylactic shock — with a frequency of 1 in 1 million doses administered).

Composition :
Active ingredients:

• purified diphtheria toxoid not less than 7.5 Lf (not less than 30 ME)
• Purified tetanus toxoid — & nbsp; not less than 3.25 Lf (not less than 60 ME)
• inactivated B. pertussis (whole cell pertussis suspension) at least 15 OU (at least 4 IU)
• HIB oligosaccharide 10 μg bound to about 25 μg SPR 197
• Hepatitis B surface antigen, purified 10 μg

Excipient: Aluminum phosphate, sodium chloride, water for injection.

Release form: & nbsp; 1-dose bottle & nbsp;

OPV vaccine

OPV — oral polio vaccine, is stabilized preparation from live attenuated poliomyelitis viruses strains Sabine type 1 and 3. & nbsp;

Why is it carried out vaccination : active immunization against polio virus 1 and 3 types.

Method of application and dosage : the vaccine is administered by mouth, in a dose of 2 drops.

Contraindications:

• hypersensitivity to neomycin, polymyxin, or any other component of the vaccine.
• patients suffering from primary and secondary immunodeficiency, Advanced Inactivated Polio Vaccine Recommended (IPV).

In accordance with the recommendations of the Extended Program Immunizations symptomatic and asymptomatic virus infection human immunodeficiency is not a contraindication for OPV immunization.

Vaccine reactions:
Minor general reactions: malaise, weakness, loss of appetite.
Rare reactions:

• development of signs and symptoms of paralytic poliomyelitis possible in vaccinated within 30 days and susceptible contacts in within 60 days after vaccination, frequency of occurrence — & nbsp; 1 case per 10 million vaccinated and susceptible contacts;
• allergic reactions to vaccine components.

Composition :
Active ingredients:

• live attenuated strains of Sabin polio virus type 1 (LSc, 2 ab) with an activity of 106.0 СCID50
• live attenuated strains of Sabin type 3 polio virus (Leon, 12a, 1b) with an activity of 105.8 CCID50.

Excipients: & nbsp;

• magnesium chloride
• arginine
• polysorbate
• neomycin sulfate
• polymyxin B sulfate
• purified water.

Form of issue : vials of 10 and 20 doses

IPV vaccine

IPV vaccine — inactivated polio vaccine, which is a stabilized preparation from inactivated poliomyelitis viruses of Sabin strains type 1, 2 and 3. & nbsp;

Patients suffering from primary and secondary immunodeficiency, it is recommended to use advanced inactivated poliomyelitis vaccine (IPV).

Why is it carried out vaccination : active immunization against polio virus 1,2 and 3 types.

Method of application and dosage : the vaccine is intended only for intramuscular administration in anterolateral surface of the left thigh for children under 1 year old, at a dose of 0.5 ml.

Contraindications: increased sensitivity to neomycin, polymyxin, or any other component vaccines.

Vaccine reactions:
Minor general reactions: malaise, weakness, loss of appetite.
Rare reactions: allergic reactions to vaccine components.

Composition :

• Inactivated polio virus type 1 (Mahoney)
  40 D antigenic units

• Inactivated polio virus type 2 (MEF 1)
  8 D antigenic units

• Inactivated polio virus type 3 (Saukett)
  32 D antigenic units

Release form: vials of 1 dose

PCV vaccine

PCV vaccine — pneumococcal polysaccharide conjugated adsorbed 13-valent vaccine. PCV contains 90% of serotypes that cause the development of invasive pneumococcal infections (IPIs) that are resistant to antibiotics.

Why is it carried out vaccination : immunization against pneumococcal infection.

Method of administration and dosage : the vaccine is intended only for intramuscular injection into the anterolateral surface of the left thigh in children under 1 year old, & nbsp; in the shoulder of children aged 12 months, in a dose of 0.5 ml.

Contraindications:

• acute period of infectious, non-infectious and chronic diseases (until complete recovery or the onset of remission)
• severe generalized allergic reactions, anaphylactic shock and other hypersensitivity reactions when previous administration of the vaccine
• individual intolerance to the components of the drug

Reaction to introduction vaccines:

• Very common: slight tenderness at the injection site vaccines less than 3 days. Reactions disappear without consequences and do not require medical intervention.
• Rare: slight increase in body temperature
• Very rare: serious allergic reactions in 1 case to million vaccinated.

Ingredients:
Active ingredients:

• pneumococcal & nbsp; polysaccharide of serotypes 1,3,4,5,6A, 7F, 9V, 14, 18C, 19A, 19F and 23F in an amount of 2.2 mcg;
• pneumococcal & nbsp; polysaccharide serotype 6B — 4.4 μg;
• diphtheria protein & nbsp; CPM — 34 mcg.

Excipients:

• aluminum phosphate
• polysorbate
• sodium chloride
• water for injection

Form of issue: 1-dose bottle & nbsp;

MMR vaccine

MMR vaccine & nbsp; — vaccine against measles, mumps and rubella, which are live attenuated viruses measles, mumps and rubella.

Why is it carried out vaccination: active immunization against measles, epidparotitis and & nbsp; rubella & nbsp;

Method of application and dosage : the vaccine is intended only for subcutaneous injection into shoulder in a dose of 0.5 ml.

Contraindications:

• acute somatic and infectious diseases
• a history of allergic or anaphylactic reactions to vaccine components (neomycin and chicken protein)
• pregnancy
• leukemia
• severe anemia and other severe blood diseases, including malignant
• severe renal dysfunction
• decompensated heart disease
• malignant neoplasms < / li>

Reaction to introduction vaccines:

• Very common: local reaction in the form of redness and soreness at the injection site.
• Often: fever, rash.
• Rare: fever and seizures …
• Very rare: inflammation of the brain and spinal cord (encephalomyelitis in 1 case per 1 million vaccinated), serious allergic reactions in 1 case per million vaccinations, thrombocytopenia in 1 case per 30,000-40,000 vaccinations, allergic reactions (anaphylactic shock) in 3.5 cases per 10 million vaccinations

Reactions to the rubella component of MMR vaccine:
Arthralgias and arthritis in adolescent girls and adult women, lasting from a few days to 2 weeks. These reactions go away on their own without treatment.

Ingredients : & nbsp;

Active ingredients:

• attenuated measles viruses (not less than 1000 TDC50)
• Epidparotitis (5000 TDC50)
• Rubella (1000 TDC50)

Excipients:

• partially hydrolyzed gelatin
• sorbitol
• traces of neomycin
• water for injection

Form of issue: 5,10-dose bottle

DPT vaccine

DPT is an adsorbed diphtheria-tetanus-pertussis vaccine, which is a homogeneous liquid that contains purified diphtheria and tetanus toxins, inactivated pertussis particles.

DPT vaccine can be administered safely and effectively simultaneously with vaccines against tuberculosis, poliomyelitis, measles, rubella, Epidparotitis and other vaccines of the preventive vaccination calendar.

Why is it carried out vaccination : active immunization against diphtheria, pertussis, tetanus

Method of application and dosage : the vaccine is intended only for intramuscular administration in the anterolateral surface of the thigh for children under 18 months or in the shoulder for children in over 18 months of age, in a dose of 0.5 ml.

Contraindications:

• hypersensitivity to any of the components vaccine
• a serious reaction to a previous dose of the combination vaccine or any of its components.

Vaccine reaction:
Common local reactions: redness, induration, soreness.
General reactions: irritability, tearfulness, a slight rise in temperature above 380C usually occurs within 48 hours after vaccination and in most cases disappear on their own within two to three days without medical assistance.

All local and general reactions disappear without consequences.

Rare collateral reactions :

• Increase in body temperature above 39.5 ° С (1 case per 15 & nbsp; 000 doses administered)
• Febrile convulsions (1 case per 12 & nbsp; 500 doses administered)
• Constant crying for more than 3 hours within 48 hours after vaccine administration (1 case per 3000 doses administered)
• Allergic reactions (urticaria, Quincke’s edema, anaphylactic shock — with a frequency of 1 case 1 million doses administered)

Composition :

Active ingredients:

• purified diphtheria toxoid not less than 20 Lf (not less 30 ME),
• Purified tetanus toxoid & nbsp; & nbsp; & nbsp; not less 7.5 Lf (not less than 40 ME),
• inactivated B. pertussis (whole-cell antipertussis suspension) not less than 12 OU,

Excipients:

• aluminum hydroxide not more than 2.5 mg / ml
• thiomersal not more than 0.1 mg / ml

Release form: & nbsp; 10th dose bottle & nbsp;

ADS vaccine

ADS — adsorbed diphtheria-tetanus toxoid is a homogeneous liquid containing purified diphtheria and tetanus toxins.

Why is it carried out vaccination : active immunization against tetanus and diphtheria.

ADS-toxoid is used:

• Children who have had whooping cough (from 3 months of age to reaching 6 years of age).
• Children who have contraindications to the introduction of DPT vaccine.
• Children aged 4-5 years, inclusive, who have not previously been vaccinated against diphtheria and tetanus.

Contraindications :

• hypersensitivity to any of the components toxoid or a serious reaction to a previous dose of toxoid
• acute infectious and non-infectious diseases — vaccinations carried out no earlier than 2-4 weeks after recovery. In milder forms diseases (rhinitis, slight hyperemia of the pharynx, etc.), vaccination is allowed after disappearance of clinical symptoms
• chronic diseases — vaccinations are carried out upon reaching complete or partial remission
• neurological changes — vaccinate after exclusion process progression
• allergic diseases — vaccinations are carried out in 2-4 weeks after the end of the exacerbation, with stable manifestations of the disease (localized skin phenomena, latent bronchospasm, etc.) are not contraindications to vaccination, which can be carried out in the background appropriate therapy.

Method of application and dosage : the vaccine is intended only for intramuscular administration in shoulder, in a dose of 0.5 ml

Reaction to the vaccine:
A common local reaction: redness and soreness at the injection site.
General reaction: malaise, weakness.

All local and general reactions disappear without consequences and not require medical attention.

Rare side reactions: allergic reactions (angioedema, polymorphic rash, urticaria and anaphylactic shock) with a registration rate of 1 per million doses administered.

Ingredients:

Active ingredients:

• purified diphtheria toxoid not less than 30 Lf (not less 60 ME)
• purified tetanus toxoid & nbsp; not less than 20 Lf (not less than 80 ME)

Excipient:

• aluminum hydroxide
• thiomersal

Release form: 10-dose bottle & nbsp;

ADS-M vaccine

ADS-M — adsorbed diphtheria-tetanus toxoid with a low content of antigens. Vaccine is a homogeneous liquid containing purified diphtheria and tetanus toxins. The toxoids are adsorbed on aluminum hydroxide. Can be safely and effectively administered concurrently with other vaccines vaccination calendar.

Why is it carried out vaccination: active immunization against tetanus and diphtheria

Contraindications :

• hypersensitivity to any of the components toxoid
• serious reaction to a previous dose of toxoid

Method of administration and dosage : vaccine intended only for intramuscular injection into the shoulder, in a dose of 0.5 ml

Reaction to the vaccine:
A common local reaction: redness and soreness at the injection site.
General reaction: malaise, weakness.

All local and general reactions disappear without consequences and not require medical attention.

Rare side reactions: allergic reactions (angioedema, polymorphic rash, urticaria and anaphylactic shock) with a registration rate of 1 per million doses administered.

Ingredients:
One 0.5 ml dose contains

Active ingredients:

• purified diphtheria toxoid not less than 10 Lf
• purified tetanus toxoid & nbsp; not less than 10 Lf

Excipients: aluminum hydroxide

Release form: & nbsp; 10-dose vial

Sources of information:

Life-saving vaccines.
Posted by
1. Aitmurzaeva G.T.
2. Zhumagulova G.Zh.
3. Shergalieva A.K.

Reviewer:
1. Plotnikova O.D.